CB-6644 OPTIONS

TAK-243 preferentially certain to UBA1 more than the related E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 diminished levels of ubiquitylated proteins, improved markers of proteotoxic tension and DNA injury anxiety. In vivo, TAK-243 decreased leukemic load and targeted leukemic stem cells devoid of proof of to